Hair loss can occur either in acute or chronic hypervitaminosis A. Loss of eyebrows and eyelashes can occur in chronic hypervitaminosis A which can occur in a number of conditions, either due to enthusiastic overdosing or due to intentional prescription of high doses for diseases such as acne, retinal disorders with night blindness, and others. The cutaneous manifestations include dry, rough, and scaly skin. Chronic hypervitaminosis A is also becoming increasingly common with use of retinoids for various skin disorders. Acitretin has been noted to cause a high incidence of diffuse hair loss. Premature teloptosis may be a prime factor in hair loss induced by retinoids.
Eight of 69 eyes receiving intra-arterial chemotherapy with melphalan for retinoblastoma were found to develop a cutaneous periocular erythema with partial loss of eyelashes. Gobin et al. also reported a 12.6% incidence of madarosis following intra-arterial chemotherapy for retinoblastoma. Moti and Fausel described a case of cyclical alopecia areata including the eyebrows and eyelashes after treatment with paclitaxel and carboplatin. Other drugs which have been implicated in hair loss due to anagen effluvium are adriamycin, cyclophosphamide, daunorubicin, epirubicin, etoposide, ifosfamide, irinotecan, topotecan, vindesine, and vinorelbine.[98,113]
Other drugs commonly attributed to causing madarosis are miotics, anticoagulants, anti-cholesterol drugs, antithyroid drugs, propranolol, valproic acid, boric acid, and bromocriptine.[21,99] Anticoagulants in high doses have been found to produce loss of scalp, pubic, axillary, and facial hair with loss of eyebrows after a latent period of a few weeks of treatment with dextran and heparin. Propranolol can cause diffuse alopecia along with loss of eyebrows due to telogen effluvium, usually after three months of therapy. Loss of medial aspect of eyebrows can be seen in fetuses exposed to valproic acid. Diffuse alopecia including that of eyebrows has been described due to chronic ingestion of mouthwashes containing boric acid. There was complete reversal following stopping the practice. Levodopa has been noted to cause severe diffuse alopecia within three months of daily use. Hair loss can occur soon after starting topical minoxidil therapy (due to detachment of club hairs following resting hairs reentering anagen), and after cessation of therapy (due to telogen effluvium).
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Diet and supplements. Hair loss caused by a vitamin deficiency or eczema can be addressed with a healthy diet and targeted vitamins and supplements. Make sure you’re getting plenty of vitamins A, B and D by eating leafy greens, nuts and seeds, fish, eggs and whole grains. If you have any gaps in your diet, take the necessary supplements to promote hair growth. Your doctor can give you direction about what to eat and take for support.
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Hypoproteinemia causes loss of hair due to premature onset of telogen. Loss of eyebrow hair has been reported due to chronic zinc deficiency in a patient receiving only parenteral nutrition for 2 months. Acrodermatitis enteropathica is an inherited disorder of zinc deficiency which shows loss of eyebrows and lashes in addition to cutaneous manifestations.[72,73] Biotin deficiency can result in encephalopathy, neurological disorders, skin desquamation, and loss of eyebrows and eyelashes. Iron deficiency may be a possible cause for diffuse telogen hair loss; its exact role however is subject to speculation.
Cyproterone acetate works in several ways. It not only competitively blocks DHT from binding to its receptors at target tissue (Gilman et al., 1990), but it is also a progestogen that lowers testosterone levels by decreasing the release of luteinizing and follicle-stimulating hormones through pituitary-mediated supression (Gilman et al., 1990, Varothai and Bergfeld, 2014). An open intervention study of 80 women who received treatment with spironolactone (200 mg daily) or cyproterone acetate (50 mg daily or 100 mg for 10 days per month if premenopausal) showed that three of four patients demonstrated an improvement or stabilization of their disease with no difference of effect between the therapies received (Sinclair et al., 2005).
Physicians such as dermatologists and plastic surgeons have long recommended essential vitamins and supplements for hair growth to women and men. Now read why top medical experts including Dr. Craig Ziering and Dr. Steven Dayan have been telling their patients for years about Viviscal hair growth supplements to help grow thicker, longer and healthier looking hair.
There can be any number of different factors contributing to your hair loss. If you’re reading this and thinking, “well I have that and that, and am going through that,” then you may already have an idea of what is a contributing cause for you. You may already be doing much of what is suggested here and may learn of additional ideas to consider trying.