Androstenedione, which is mostly produced in the ovary and adrenal glands, is converted to testosterone by 17β-hydroxysteroid dehydrogenase. Testosterone then circulates throughout the body to reach its target tissues. Androgen-metabolizing enzymes have been found in many parts of the hair follicle (Table 1; Bolognia et al., 2012). The presence of those enzymes makes the pilosebaceous unit a site of androgen metabolism and synthesis (Fazekas and Sandor, 1973). Circulating free testosterone either binds to intracellular androgen receptors in the hair bulb and dermal papilla, which facilitates miniaturization of the follicle, or is metabolized into dihydrotestosterone (DHT) by the enzyme 5-alpha-reductase. DHT then binds the same receptor but with much greater affinity (Kaufman, 2002, Levy and Emer, 2013). Of the androgens depicted in Figure 1, only DHT and testosterone bind to androgen receptors (Burger, 2002).
There is some evidence of a link between baldness and prostate cancer and other diseases. Harvard Medical School reports that men with vertex baldness have 1.5 times more of a risk of developing prostate cancer than men without bald spots. The risk of coronary artery disease is also more than 23 percent higher in men with vertex bald spots. Investigations are ongoing as to whether there is a link between DHT levels and metabolic syndrome, diabetes, and other health conditions.
That's why I've designed a system I call The Gottfried Protocol, a step-by-step, integrative approach to natural hormone healing that emphasizes lifestyle design first and foremost. It's based on decades of research, my education at Harvard Medical School, my own experiences with hormonal imbalances, my belief in peer-reviewed, well-performed randomized trials to support my recommendations, and what I've learned from patients over the past 20-plus years of practicing medicine. The Gottfried Protocol engages only the top hierarchy of scientific evidence and has been proven in scores of women in my practice.
A number of skin and hair disorders can lead to eyebrow hair loss and sometimes it may be linked to systemic diseases like lupus. Specific skin and hair disorders that are most likely to lead to eyebrow thinning and hair loss have been discussed below but other conditions like psoriasis may also be involved if it occurs on the eyebrow or forehead. Eyebrow hair loss may occur in people on chemotherapy (cancer medication) and with radiation therapy to the head.
These are only a few of the common myths heard by physicians and other hair loss specialists on a daily basis. The American Hair Loss Council suggests that you first have your hair loss diagnosed by a competent dermatologist who sees hair loss patients on a regular basis. Once you know the diagnosis you will have a better understanding of exactly which treatment option may be best for you.
Karen Hellesvig-Gaskell is a broadcast journalist who began writing professionally in 1980. Her writing focuses on parenting and health, and has appeared in “Spirituality & Health Magazine" and “Essential Wellness.” Hellesvig-Gaskell has worked with autistic children at the Fraser School in Minneapolis and as a child care assistant for toddlers and preschoolers at the International School of Minnesota, Eden Prairie.
Here is one small European study which looked at 20 pre-menopausal women with female pattern hair loss to check their serum levels of estradiol, free and total testosterone, SHBG, LH, FSH, and DHEAS. These levels were compared to those of a control group without hair loss. Estradiol is one of the three naturally occurring forms of estrogen found in the body.
If you’ve overplucked your brows too many times, you may have caused trauma to the follicles in the meantime, signalling not only those hairs you plucked to stop growing back, but also the hairs in surrounding areas. The good news: If the hair follicles aren’t dead, they can possibly be shaken from their resting state with a good brow enhancer. (like WINK  yes of course, we have to say it). There’s no sure bets, but it’s worth a try–plus Wink has a money-back guarantee!
Contact dermatitis causes skin inflammation and when severe it can affect the hair follicles as well. It can either be due to some irritant making contact with the skin of the eyebrows or due to a substance to which a person has an allergy. This gives rise to the two types of contact dermatitis – irritant contact dermatitis or allergic contact dermatitis. Substances that could cause contact dermatitis at the eyebrow includes eye makeup including eyebrow pencils, hair removal creams and waxes, other cosmetics, hair dyes and scalp hair styling products.

The first step in treatment is to identify the cause of the hair loss. Then, treat it appropriately. If an internal cause is the culprit, it should be addressed — for example, thyroid medication for thyroid disease or supplements for a nutritional deficiency. External skin conditions are often treated with topical medications, and, once treated, the hair loss usually recovers. I often recommend Latisse as an adjunctive treatment. Though frequently associated with eyelash lengthening, it is a great option for thickening brows. In fact, people with brows that thin with aging (I typically don't see this in women under 50) may want to opt for Latisse.
Various techniques have been described over the years. Nylon implants were used by some people. Now, they are banned in many countries because of sequelae-like scarring and infection. Follicular unit transplantation has been found to give very good results[195] and is now the procedure of choice for most types of hair transplantation. The details of the procedure with respect to eyebrow and eyelash reconstruction will be discussed here.
See a dermatologist for itchy skin or rashes around your brows. These patches may indicate a skin infection or interaction with a new beauty product or environmental trigger. You could also have inflammation from dermatitis or psoriasis.[32] These conditions don’t actually cause hair loss, but they can lead to it if you rub and scratch the affected areas.

What’s more likely is that telogen effluvium is at play (again). In addition to hormone fluctuations, this type of hair loss happens when there is a drastic dip in protein in the diet or sudden weight loss. For example, if you are sick and can only consume liquids for a month. “If you have protein levels that drop dramatically, your hair follicles go into hibernation, and you can see sudden acute hair loss that shows up three to six months later,” says Dr. Katta.
Stress: Emotional and physiological stress can trigger a few hair loss conditions that can affect your eyebrows. Telogen effluvium, for instance, can cause your hair to shed. Then there’s trichotillomania, which is a psychiatric condition caused by stress that is characterized by the urge to pull out your own hair (which could be from your eyebrows, eyelashes or scalp).
Thallium poisoning should be suspected in any patient manifesting nervous system and gastrointestinal symptoms along with alopecia. The hair loss affects the scalp, periocular hair, limbs, and sometimes the axillae. Examination of the hair roots under a microscope using polarized light shows distorted anagen roots and several black zones in continued poisoning.[118]
The recipient sites in the eyebrow can be conveniently made with 20 to 22-gauge needles parallel to the skin, so that hair grows flat on the skin and does not stick out from the face. About 150 hairs are required for a full eyebrow graft. Poddar et al. described good results with a technique of creating recipient tracks with the erbium yttrium aluminium garnet laser.[202]
During pregnancy, high concentration of estrogen levels in women result in the development of thicker, stronger, longer and healthier looking hair. Following pregnancy however, women tend to fret and think that they’re losing their hair when in fact they’re merely shedding the excess hair that the excess oestrogen created. The hair that was in a prolonged anagen stage are now all shifting into telogen (resting phase) to make way for new hair growth. This type of hair loss is comes under the condition known as telogen effluvium but the good news is that when oestrogen levels have returned to normal, your hair will too.
When you choose dōTERRA®, you are choosing essential oils gently and carefully distilled from plants that have been patiently harvested at the perfect moment by experienced growers from around the world for ideal extract composition and efficacy. Each dōTERRA essential oil is also carefully and thoroughly tested using the strict CPTG Certified Pure Therapeutic Grade® quality protocol.
While female hair loss may not cause physical pain, it does cause mental anguish. Fortunately, in many cases, female hair loss can be successfully treated with today’s advanced nonsurgical and surgical treatment options. After a diagnosis has been confirmed, Dr. Yaker will create a customized treatment plan depending on one’s hair characteristics, the level of hair loss and the aesthetic goals of the patient.
Hansen's disease, also known as leprosy, is an infection of the skin and nerves caused by the bacterium Mycobacterium leprae. The disease often affects the skin of the eyebrow region, leading to loss of sensation and permanent loss of the eyebrow hairs. There are numerous other rare and uncommon causes of eyebrow hair loss, including vitamin A toxicity, nutritional disorders and other dermatological disorders. If you experience loss of eyebrow hair, see your doctor to evaluate the cause and to discuss a treatment plan. 
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