Estrogen is the dominant female sex hormone which is essential for the development of female characteristics. It can however be also found in men as well, but in lower quantities. Likewise there are also few quantities of the male sex hormones Testosterone, in female body. Estrogen is not a single hormone but actually a group of female sex hormones which include estradiol, estriol and estrone hormones. Estrogen is made in the ovaries and to a lesser extent in other bodily tissues. 

DLE is an autoimmune condition and is the most common form of chronic cutaneous lupus erythematosus.[35] Clinically, the lesions start as discoid erythematous patches which then develop into plaques with follicular plugging and scaling. Eyelid findings include blepharitis, lid scarring, entropion, and ectropion. Scaly plaques on the eyelids with loss of hair follicles results in madarosis[60] [Figure 3]. Numerous studies have reported the mimicking of a chronic blepharitis by DLE.[35,61–63] A high index of suspicion is necessary in such cases, where the diagnosis is very often delayed by months to years.[35] Biopsy with histopathological examination should be done to confirm the diagnosis. Treatment with hydroxychloroquine results in a regrowth of the eyelashes.[61]
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